Cure for radiation sickness found?

[cyberdalekyeti]

Finally some good news to report Jewish-American scientists discovers cure for radiation sickness. http://www.ynetnews.com/articles/0,7340,L-3748014,00.html (http://www.ynetnews.com/articles/0,7340,L-3748014,00.html)

This is great and has to be one of the biggest break through in years.

John

[Samm]

Hooray! Now Israel can nuke Iran with impunity...

[sironin]

Of all the things Star Trek could get right about possible future medical technology, this was one of the ones I had thought least likely.

Wow.

[LouC]

Not being schooled in the science of radiation therapy for cancer treatments could this not have an immediate wide ranging applicability in that area upon approval?

[LouC]

Of all the things Star Trek could get right about possible future medical technology, this was one of the ones I had thought least likely.

Wow.

That is one I always wondered about as well from the series.

I too thought it was the least likely.

[CaughtInTheMiddle]

Heroes!!!

[LouC]

Heroes!!!

I hate to say it but as I began to read the article, I was thinking along the same lines, but another thought creeped into my mind, a terrible one, what if this news accelerated terrorists plans for dirty bomb attacks against large population centers?

Argh!!!!!!!!

[CaughtInTheMiddle]

I hate to say it but as I began to read the article, I was thinking along the same lines, but another thought creeped into my mind, a terrible one, what if this news accelerated terrorists plans for dirty bomb attacks against large population centers?

Argh!!!!!!!!

Yeah, and this discovery doesn't help if the bomb, you know, lands on you. But I would much rather talk about these brilliant minds than Michael Jackson, talking heads or twittering from the sidelines.

And I'm convinced that, at some point in the future, all countries will have mobile nuclear weapons. We'll all be long gone but it's inevitable. I've always wondered how that fact will change foreign policy for countries around the world.

[BillBrown]

I read every once in a while about a cure for certain cancers, AIDS, MS. Just today Drudge has a story about a cure for muscular dystrophy.

In a week these 'cures" leave the radar and are never heard from again.

[CaughtInTheMiddle]

I read every once in a while about a cure for certain cancers, AIDS, MS. Just today Drudge has a story about a cure for muscular dystrophy.

In a week these 'cures" leave the radar and are never heard from again.

Very, very true. But if this one makes it through, it's major. And it's been kept secret (for good reason) for awhile now. But I'm not sure how they do clinical trials on humans. Maybe they just wait for a person to be affected with radiation and then test it on them. Either way, it sounds like they found a way to protect monkeys from radiation poisoning. That is, without a doubt, a stepping stone to a cure for humans.

[EmmanuelGoldstein]

Not being schooled in the science of radiation therapy for cancer treatments could this not have an immediate wide ranging applicability in that area upon approval?
Mornin' Lou :hug:

Gudkov's discovery may also have immense implications for cancer patients by enabling doctors to better protect patients against radiation. Should the new medication enable cancer patients to be treated with more powerful radiation, our ability to fight the disease could greatly improve

They suspected (but couldn't prove) that my Mom's cancer resulted from radiation exposure from treatment for a benign glomus in the early 60's. The opposite parotid gland was in the direct field. Because of that, her docs were limited in the area and amount of radiation they could use against the cancerous tumor.

[meggers49]

Hooray! Now Israel can nuke Iran with impunity...

or Israel won't have to worry when the nuts in Iran nuke them? since.....um....Iran is the one threatening......but .....whatever.

[EmmanuelGoldstein]

Another test on humans, who were given the drug without being exposed to radiation, showed that the medication does not have side-effects and is safe.

Hmm. I don't hardly believe that. Everything has side-effects...

[Greyclouds]

Finally some good news to report Jewish-American scientists discovers cure for radiation sickness. http://www.ynetnews.com/articles/0,7340,L-3748014,00.html (http://www.ynetnews.com/articles/0,7340,L-3748014,00.html)

This is great and has to be one of the biggest break through in years.

John

Woah woah woah! Hold your horses! If this article is talking about the recently accepted Gudkov article in the journal Free Radical, then they're REALLY misleading their readers!!!

Gudkov just published an article on the use of carbon fullerenes (aromatic carbon compounds) to reduce oxidative stress on DNA after radiation. They only used mouse models, and the best recovery outcome was when the animals were injected with the fullerenes prior to radiation.

From the article's abstract:
... The most significant protective effect was demonstrated when 1 mg/kg dosage of C60HyFn was administered before irradiation. The outcome of the substance testing is 15% survival rate of irradiated animals at 30 days of observation, and prevention of noticeable weight loss characteristic for radiation impact, versus unprotected control animals. In conclusion, results of the study obviate that the apparent protective action of C60HyFn in vivo is determined by its considerable ability to decrease X-ray-generated reactive oxygen species. Based on the results and that neat C60 is nontoxic, actually in the hydrated form, without side effects and with sufficient radioprotective effects in low doses, C60HyFn may be considered as a novel antioxidant agent, which substantially diminishes the harmful effects of ionizing radiation.

http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T38-4WJBBT9-3&_user=669286&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000036298&_version=1&_urlVersion=0&_userid=669286&md5=26f300f362826a68cb3aa18ac046cda9


AH! I found the Journal article that the blog was talking about! It was in Science, but it was published LAST YEAR in APRIL!! I see some significant problems with their approach as well:

http://www.sciencemag.org/cgi/content/full/sci;320/5873/163?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=gudkov&searchid=1&FIRSTINDEX=0&resourcetype=HWCIT

From the article summary:

Tumor cells persist in the body because they are able to block apoptosis, by activating a transcription factor known as nuclear factor-kappaB. "Many in the cancer field are trying to inhibit NF-kappaB in tumor cells in order to let them commit suicide," says Andrei Gudkov, a co-author and a molecular geneticist at Roswell. "We thought, 'Why not try to do the opposite in normal cells to help them survive radiation?' "

Burdelya and her colleagues knew that human gut and immune cells activate NF-kappaB when flagella, bacteria's whiplike tails, tickle a cell surface protein called Toll-like receptor 5. Drawing upon this insight, they developed an NF-kappaB-activating drug, dubbed CBLB502, by modifying a small fragment of a Salmonella flagella. The team found that mice and rhesus monkeys injected with CBLB502 45 minutes to 24 hours before exposure to lethal radiation were more likely to survive, or survive longer, than animals that did not receive the drug. The drug also helped prevent death in mice when administered an hour after the animals received a radiation dose. There were no obvious side effects to the drug, and in another experiment, the researchers showed that radiation was still effective in treating tumors in mice that had received CBLB502.
http://www.sciencemag.org/cgi/content/full/sci;320/5873/163?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=gudkov&searchid=1&FIRSTINDEX=0&resourcetype=HWCIT

Knowing just a tiny bit about NF kappaB, it is the transcription factor that prevents cancer cells from dying and actually circumvents the cell's ability to "die" (apoptosis) which is critical in multi-celled organisms like us! It also causes some cells to continue to grow; this is primarily why cancer cells form tumors!

So, this peptide that they're injecting into animals actually causes an immune response that activates NF KappaB inside your cells. This COULD exacerbate a genetic proclivity towards cancer (following irradiation of your body), so I would strongly suggest that the research on this treatment continue and not be "fast-tracked."

NF kappaB is a pretty potent transcription factor...

[Greyclouds]

Hmm. I don't hardly believe that. Everything has side-effects...

You are correct.

Even though it is a peptide, it can cause an immune response in a human being (which is what the investigators wanted!).

Immune response to stimuli differs from person to person; an infection that just left you with a slight rash for two days could end up causing cardiac arrest in another person.

[EmmanuelGoldstein]

Woah woah woah! Hold your horses! If this article is talking about the recently accepted Gudkov article in the journal Free Radical, then they're REALLY misleading their readers!!!

Gudkov just published an article on the use of carbon fullerenes (aromatic carbon compounds) to reduce oxidative stress on DNA after radiation. They only used mouse models, and the best recovery outcome was when the animals were injected with the fullerenes prior to radiation.

From the article's abstract:


http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T38-4WJBBT9-3&_user=669286&_rdoc=1&_fmt=&_orig=search&_sort=d&_docanchor=&view=c&_acct=C000036298&_version=1&_urlVersion=0&_userid=669286&md5=26f300f362826a68cb3aa18ac046cda9


AH! I found the Journal article that the blog was talking about! It was in Science, but it was published LAST YEAR in APRIL!! I see some significant problems with their approach as well:

http://www.sciencemag.org/cgi/content/full/sci;320/5873/163?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=gudkov&searchid=1&FIRSTINDEX=0&resourcetype=HWCIT

From the article summary:


http://www.sciencemag.org/cgi/content/full/sci;320/5873/163?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=gudkov&searchid=1&FIRSTINDEX=0&resourcetype=HWCIT

Knowing just a tiny bit about NF kappaB, it is the transcription factor that prevents cancer cells from dying and actually circumvents the cell's ability to "die" (apoptosis) which is critical in multi-celled organisms like us! It also causes some cells to continue to grow; this is primarily why cancer cells form tumors!

So, this peptide that they're injecting into animals actually causes an immune response that activates NF KappaB inside your cells. This COULD exacerbate a genetic proclivity towards cancer (following irradiation of your body), so I would strongly suggest that the research on this treatment continue and not be "fast-tracked."

NF kappaB is a pretty potent transcription factor...

Thank you!

[Samm]

or Israel won't have to worry when the nuts in Iran nuke them? since.....um....Iran is the one threatening......but .....whatever.

Uh... maybe you are not aware... when it comes to nukes, he who bombs first wins. It is not the radiation from Iranian nukes that Israel fears.

[jimjames418]

This is not a cure for radiation sickness, it is a method of preventing radiation sickness. Two entirely different things.